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Philippe Horvath, Rodolphe Barrangou. CRISPR/Cas, the Immune System of Bacteria and Archaea //Science. 2010. V. 327. P. 167–170. DOI: 10.1126/science.1179555.

[PDF] from umn.edu…, R Barrangou - Science2010 - sciencemag.org
... E-mail: philippe.horvath{at}danisco.com (PH), rodolphe.barrangou{at}danisco.com (RB). ... Science
senior editor Guy Riddihough talks with author Rodolphe Barrangou on the prokaryotic ... of 45
CRISPR-associated (Cas) protein families and multiple CRISPR/Cas subtypes exist in ... 
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SJ Labrie, JE Samson… - Nature Reviews Microbiology, 2010 - nature.com
Phages are now acknowledged as the most abundant microorganisms on the planet and are 
also possibly the most diversified. This diversity is mostly driven by their dynamic adaptation 
when facing selective pressure such as phage resistance mechanisms, which are ... 
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K Hegstad, T Mikalsen, TM Coque… - Clinical …, 2010 - Wiley Online Library
Mobile genetic elements (MGEs) including plasmids and transposons are pivotal in the dissemination 
and persistence of antimicrobial resistance in Enterococcus faecalis and Enterococcus 
faecium. Enterococcal MGEs have also been shown to be able to transfer resistance ... 
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K Pougach, E Semenova, E Bogdanova… - Molecular … - interscience.wiley.com
CRISPR/Cas, bacterial and archaeal systems of inter- ference with foreign genetic elements 
such as viruses or plasmids, consist of DNA loci called CRISPR cas- settes (a set of variable 
spacers regularly separated by palindromic repeats) and associated cas genes. When a ... 
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[HTML] from nih.govPF Vale… - Proceedings of the Royal …, 2010 - rspb.royalsocietypublishing.org
Bacteria can acquire heritable immunity to viral (phage) enemies by incorporating phage DNA 
into their own genome. This mechanism of anti-viral defence, known by the acronym 
CRISPR, simultaneously stores detailed information about current and past enemies and ... 
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ER Westra, Ü Pul, N Heidrich, MM Jore… - Molecular … - Wiley Online Library
Skip to Main Content. ... 
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SM Hedrick, IL Ch'en… - Immunological reviews, 2010 - interscience.wiley.com
Ó 2010 John Wiley & Sons A/S • Immunological Reviews 236/2010 ... Stephen M. Hedrick Irene 
L. Ch'en Bryce N. Alves ... Authors' address Stephen M. Hedrick1, Irene L. Ch'en1, Bryce N. Alves1 
1Department of Molecular Biology, University of California, San Diego, La Jolla, CA, USA. 
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S Kienesberger, G Gorkiewicz, H Wolinski… - Microbial … - Wiley Online Library
Campylobacter fetus infection is a substantial problem in herds of domestic cattle worldwide 
and a rising threat in human disease. Application of comparative and functional genomics approaches 
will be essential to understand the molecular basis of this pathogen's interactions with ... 
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[HTML] from asm.orgKL Palmer… - mBio, 2010 - Am Soc Microbiol
Clustered, regularly interspaced short palindromic repeats (CRISPR) provide bacteria and archaea 
with sequence-specific, acquired defense against plasmids and phage. Because mobile elements 
constitute up to 25% of the genome of multidrug-resistant (MDR) enterococci, it was of ...
[HTML] from biology-direct.comV Anantharaman, D Zhang… - Biology Direct, 2010 - biology-direct.com
Thus, proteins with this domain might have a key role in the recognition and localization of 
dsRNA, including miRNAs, rasiRNAs and piRNAs hybridized to their targets. In other cases, 
this domain is fused to ubiquitin-binding, E3 ligase and ubiquitin-like domains indicating ... 
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J Carte, NT Pfister, MM Compton, RM Terns… - RNA, 2010 - rnajournal.cshlp.org
Page 1. 10.1261/rna.2230110 Access the most recent version at doi: published online
September 30, 2010 RNA Jason Carte, Neil T. Pfister, Mark M. Compton, et al. Binding
and cleavage of CRISPR RNA by Cas6 P<P Published ... 
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LA Marraffini - Future Microbiol., 2010 - Future Medicine
Bacteria have the ability to evolve fast, mainly by acquiring genetic material from related or unrelated 
species, a process known as horizontal or lateral gene transfer (HGT). There are three basic 
routes for the transfer of DNA between bacteria: transformation, transduction and ... 
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[HTML] from sfu.caM von Jan, A Lapidus, T Glavina Del Rio… - … in Genomic Sciences, 2010 - journals.sfu.ca
Archaeoglobus profundus (Burggraf et al. 1990) is a hyperthermophilic archaeon in the euryarchaeal 
class Archaeoglobi, which is currently represented by the single family Archaeoglobaceae, containing 
six validly named species and two strains ascribed to the genus 'Geoglobus' which is ... 
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[PDF] from weizmann.ac.ilA Stern, L Keren, O Wurtzel, G Amitai… - Trends in Genetics, 2010 - Elsevier
The recently discovered prokaryotic immune system known as CRISPR (clustered regularly interspaced 
short palindromic repeats) is based on small RNAs ('spacers') that restrict phage and plasmid 
infection. It has been hypothesized that CRISPRs can also regulate self gene expression ... 
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KL Palmer, VN Kos… - Current Opinion in Microbiology, 2010 - Elsevier
Enterococci are Gram-positive bacteria that normally colonize gastrointestinal tracts of humans 
and animals. They are of growing concern because of their ability to cause antibiotic resistant 
hospital infections. Antibiotic resistance has been acquired, and has disseminated ... 
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[HTML] from plos.orgS Miquel, E Peyretaillade, L Claret, A de Vallée… - PloS one, 2010 - dx.plos.org
We report here the complete genome sequence of E. coli LF82, the reference strain of 
adherent-invasive E. coli associated with ileal Crohn's disease. The LF82 genome of 4,881,487 
bp total size contains a circular chromosome with a size of 4,773,108 bp and a plasmid of ... 
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[HTML] from plos.orgBR Levin… - PLoS Genetics, 2010 - dx.plos.org
CRISPR is the acronym for the adaptive immune system that has been found in almost all archaebacteria 
and nearly half the eubacteria examined. Unlike the other defenses bacteria have for protection 
from phage and other deleterious DNAs, CRISPR has the virtues of specificity, memory, ... 
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JC Snyder, MM Bateson, M Lavin… - Applied and …, 2010 - Am Soc Microbiol
It is currently difficult to detect unknown viruses in any given environment. The recent discovery 
of CRISPR (clusters of regularly interspaced short palindromic repeats) loci within bacterial and 
archaeal cellular genomes may provide an alternative approach to detect new viruses. It ...
DJ Rankin, M Bichsel… - Journal of Evolutionary Biology - Wiley Online Library
Natural selection ultimately acts on genes and other DNA sequences. Adaptations that are good 
for the gene can have adverse effects at higher levels of organization, including the individual 
or the population. Mobile genetic elements illustrate this principle well, because they can ... 
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H Strnad, A Lapidus, J Paces, P Ulbrich… - Journal of …, 2010 - Am Soc Microbiol
The genome of Rhodobacter capsulatus SB 1003 consists of a single chromosome containing 
3,738,958 bp and a circular plasmid of 132,962 bp. Both the chromosome and the plasmid have 
relatively high GC content (66.6%) that made DNA sequencing difficult. The project was ... 
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[PDF] from biomedcentral.comJ Brunner, FRA Wittink, MJ Jonker… - BMC …, 2010 - biomedcentral.com
Jorg Brunner (j.brunner@vumc.nl) Floyd RA Wittink (rawittink@uva.nl) Martijs J. Jonker 
(mjjonker@uva.nl) Mark de Jong (hmdejong@uva.nl) Timo M. Breit (tmbreit@uva.nl) Marja 
L. Laine (m.laine@acta.nl) Johannes J. de Soet (jdsoet@acta.nl) Wim Crielaard ... 
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