Abstract

http://www.ncbi.nlm.nih.gov/pubmed/19726441?dopt=Abstract

J R Soc Interface. 2009 Sep 2. [Epub ahead of print]

Nanoparticles, human health hazard and regulation.

Seaton ATran LAitken RDonaldson K.

Safety of Nanomaterials Interdisciplinary Research Centre, Institute of Occupational Medicine, , Research Avenue North, Riccarton, Edinburgh EH14 4AP, UK.

New developments in technology usually entail some hazard as well as advantage to a society. Hazard of a material translates into risk by exposure of humans and/or their environment to the agent in question, and risk is reduced by control of exposure, usually guided by regulation based on understanding of the mechanisms of harm. We illustrate risks relating to the causation of diseases associated with exposure to aerosols of combustion particles and asbestos, leading to paradigms of particle toxicity, and discuss analogies with potential exposure to manufactured nanoparticles (NPs). We review the current understanding of the hazard of NPs derived from the new science of nanotoxicology and the limited research to date into human exposure to these particles. We identify gaps in knowledge relating to the properties of NPs that might determine toxicity and in understanding the most appropriate ways both to measure this in the laboratory and to assess it in the workplace. Nevertheless, we point out that physical principles governing the behaviour of such particles allow determination of practical methods of protecting those potentially exposed. Finally, we discuss the early steps towards regulation and the difficulties facing regulators in controlling potentially harmful exposures in the absence of sufficient scientific evidence.

PMID: 19726441 [PubMed - as supplied by publisher]

Results: 1 to 20 of 56
1.

Nanoparticles, human health hazard and regulation.

Seaton A, Tran L, Aitken R, Donaldson K.

J R Soc Interface. 2009 Sep 2. [Epub ahead of print]PMID: 19726441 [PubMed - as supplied by publisher]Related articles

2.

Sources, pathways, and relative risks of contaminants in surface water and groundwater: a perspective prepared for the Walkerton inquiry.

Ritter L, Solomon K, Sibley P, Hall K, Keen P, Mattu G, Linton B.

J Toxicol Environ Health A. 2002 Jan 11;65(1):1-142. Review.PMID: 11809004 [PubMed - indexed for MEDLINE]Related articles

3.

Do nanoparticles present ecotoxicological risks for the health of the aquatic environment?

Moore MN.

Environ Int. 2006 Dec;32(8):967-76. Epub 2006 Jul 21. Review.PMID: 16859745 [PubMed - indexed for MEDLINE]Related articles

4.

A review of carbon nanotube toxicity and assessment of potential occupational and environmental health risks.

Lam CW, James JT, McCluskey R, Arepalli S, Hunter RL.

Crit Rev Toxicol. 2006 Mar;36(3):189-217. Review.PMID: 16686422 [PubMed - indexed for MEDLINE]Related articles

5.

Changing approaches to assessment of environmental inhalation risk: a case study.

Corn JK, Corn M.

Milbank Q. 1995;73(1):97-119. Review.PMID: 7898410 [PubMed - indexed for MEDLINE]Related articles

6.

Air pollution, ultrafine and nanoparticle toxicology: cellular and molecular interactions.

Stone V, Johnston H, Clift MJ.

IEEE Trans Nanobioscience. 2007 Dec;6(4):331-40. Review.PMID: 18217626 [PubMed - indexed for MEDLINE]Related articles

7.

Naturally occurring asbestos: a recurring public policy challenge.

Lee RJ, Strohmeier BR, Bunker KL, Van Orden DR.

J Hazard Mater. 2008 May 1;153(1-2):1-21. Epub 2007 Nov 28. Review.PMID: 18180100 [PubMed - indexed for MEDLINE]Related articles

8.

Evidence-based toxicology: a comprehensive framework for causation.

Guzelian PS, Victoroff MS, Halmes NC, James RC, Guzelian CP.

Hum Exp Toxicol. 2005 Apr;24(4):161-201. Review.PMID: 15957536 [PubMed - indexed for MEDLINE]Related articles

9.

Safety and nutritional assessment of GM plants and derived food and feed: the role of animal feeding trials.

EFSA GMO Panel Working Group on Animal Feeding Trials.

Food Chem Toxicol. 2008 Mar;46 Suppl 1:S2-70. Epub 2008 Feb 13. Review.PMID: 18328408 [PubMed - indexed for MEDLINE]Related articles

10.

Risk management frameworks for human health and environmental risks.

Jardine C, Hrudey S, Shortreed J, Craig L, Krewski D, Furgal C, McColl S.

J Toxicol Environ Health B Crit Rev. 2003 Nov-Dec;6(6):569-720. Review.PMID: 14698953 [PubMed - indexed for MEDLINE]Related articles

11.

Chemical risk assessment: a review.

Hopper LD, Oehme FW.

Vet Hum Toxicol. 1989 Dec;31(6):543-54. Review.PMID: 2694585 [PubMed - indexed for MEDLINE]Related articles

12.

Combustion-derived nanoparticles: mechanisms of pulmonary toxicity.

BéruBé K, Balharry D, Sexton K, Koshy L, Jones T.

Clin Exp Pharmacol Physiol. 2007 Oct;34(10):1044-50. Review.PMID: 17714092 [PubMed - indexed for MEDLINE]Related articles

13.

Resolving the nanoparticles paradox.

Donaldson K.

Nanomed. 2006 Aug;1(2):229-34. Review.PMID: 17716112 [PubMed - indexed for MEDLINE]Related articles

14.

[Fine, ultrafine and nano- particles in the living and working setting: potential health effects and measurement of inhalation exposure]

Marconi A.

G Ital Med Lav Ergon. 2006 Jul-Sep;28(3):258-65. Review. Italian.PMID: 17144413 [PubMed - indexed for MEDLINE]Related articles

15.

Nanotoxicology for safe and sustainable nanotechnology.

Drobne D.

Arh Hig Rada Toksikol. 2007 Dec;58(4):471-8. Review.PMID: 18063532 [PubMed - indexed for MEDLINE]Related articles

16.

[Recent prevention strategies and occupational risk analysis: Control Banding and Sobane]

Ghittori S, Ferrari M, Negri S, Serranti P, Sacco P, Biffi R, Imbriani M.

G Ital Med Lav Ergon. 2006 Jan-Mar;28(1):30-43. Review. Italian.PMID: 16705887 [PubMed - indexed for MEDLINE]Related articles

17.

Health effects related to nanoparticle exposures: environmental, health and safety considerations for assessing hazards and risks.

Warheit DB, Sayes CM, Reed KL, Swain KA.

Pharmacol Ther. 2008 Oct;120(1):35-42. Epub 2008 Jul 19. Review.PMID: 18703086 [PubMed - indexed for MEDLINE]Related articles

18.

Synthetic vitreous fibers: a review of toxicology research and its impact on hazard classification.

Hesterberg TW, Hart GA.

Crit Rev Toxicol. 2001 Jan;31(1):1-53. Review.PMID: 11215691 [PubMed - indexed for MEDLINE]Related articles

19.

Interventions for preventing eating disorders in children and adolescents.

Pratt BM, Woolfenden SR.

Cochrane Database Syst Rev. 2002;(2):CD002891. Review.PMID: 12076457 [PubMed - indexed for MEDLINE]Related articles

20.

Approaches to evaluating the toxicity and carcinogenicity of man-made fibers: summary of a workshop held November 11-13, 1991, Durham, North Carolina.

McClellan RO, Miller FJ, Hesterberg TW, Warheit DB, Bunn WB, Kane AB, Lippmann M, Mast RW, McConnell EE, Reinhardt CF.

Regul Toxicol Pharmacol. 1992 Dec;16(3):321-64. Review.PMID: 1293648 [PubMed - indexed for MEDLINE]Related articles

Results: 21 to 40 of 56

21.

Research strategies for safety evaluation of nanomaterials, part IV: risk assessment of nanoparticles.

Tsuji JS, Maynard AD, Howard PC, James JT, Lam CW, Warheit DB, Santamaria AB.

Toxicol Sci. 2006 Jan;89(1):42-50. Epub 2005 Sep 21. Review.PMID: 16177233 [PubMed - indexed for MEDLINE]Related articlesFree article

22.

Monitoring of human populations for early markers of cadmium toxicity: a review.

Fowler BA.

Toxicol Appl Pharmacol. 2009 Aug 1;238(3):294-300. Epub 2009 May 9. Review.PMID: 19433102 [PubMed - indexed for MEDLINE]Related articles

23.

[Human ecology and interdisciplinary cooperation for primary prevention of environmental risk factors for public health]

Dobrowolski JW.

Przegl Lek. 2007;64 Suppl 4:35-41. Review. Polish.PMID: 18540323 [PubMed - indexed for MEDLINE]Related articles

24.

The impact of new technologies on human population studies.

Waters MD, Selkirk JK, Olden K.

Mutat Res. 2003 Nov;544(2-3):349-60. Review.PMID: 14644337 [PubMed - indexed for MEDLINE]Related articles

25.

NTP center for the evaluation of risks to human reproduction reports on phthalates: addressing the data gaps.

McKee RH, Butala JH, David RM, Gans G.

Reprod Toxicol. 2004 Jan-Feb;18(1):1-22. Review.PMID: 15013060 [PubMed - indexed for MEDLINE]Related articles

26.

Understanding population and individual risk assessment: the case of polychlorinated biphenyls.

Shields PG.

Cancer Epidemiol Biomarkers Prev. 2006 May;15(5):830-9. Review. Erratum in: Cancer Epidemiol Biomarkers Prev. 2006 Jul;15(7):1421.PMID: 16702358 [PubMed - indexed for MEDLINE]Related articlesFree article

27.

Grey goo on the skin? Nanotechnology, cosmetic and sunscreen safety.

Nohynek GJ, Lademann J, Ribaud C, Roberts MS.

Crit Rev Toxicol. 2007 Mar;37(3):251-77. Review.PMID: 17453934 [PubMed - indexed for MEDLINE]Related articles

28.

Assessing the risks of exposures to multiple chemicals with a common mechanism of toxicity: how to cumulate?

Wilkinson CF, Christoph GR, Julien E, Kelley JM, Kronenberg J, McCarthy J, Reiss R.

Regul Toxicol Pharmacol. 2000 Feb;31(1):30-43. Review.PMID: 10715222 [PubMed - indexed for MEDLINE]Related articles

29.

A toxicologic review of quantum dots: toxicity depends on physicochemical and environmental factors.

Hardman R.

Environ Health Perspect. 2006 Feb;114(2):165-72. Review.PMID: 16451849 [PubMed - indexed for MEDLINE]Related articlesFree article

30.

Particle toxicology: from coal mining to nanotechnology.

Borm PJ.

Inhal Toxicol. 2002 Mar;14(3):311-24. Review.PMID: 12028820 [PubMed - indexed for MEDLINE]Related articles

31.

Determination of a site-specific reference dose for methylmercury for fish-eating populations.

Shipp AM, Gentry PR, Lawrence G, Van Landingham C, Covington T, Clewell HJ, Gribben K, Crump K.

Toxicol Ind Health. 2000 Nov;16(9-10):335-438. Review.PMID: 11762928 [PubMed - indexed for MEDLINE]Related articles

32.

Reducing obesity and related chronic disease risk in children and youth: a synthesis of evidence with 'best practice' recommendations.

Flynn MA, McNeil DA, Maloff B, Mutasingwa D, Wu M, Ford C, Tough SC.

Obes Rev. 2006 Feb;7 Suppl 1:7-66. Review.PMID: 16371076 [PubMed - indexed for MEDLINE]Related articles

33.

Mechanisms of genotoxicity of particles and fibers.

Schins RP.

Inhal Toxicol. 2002 Jan;14(1):57-78. Review.PMID: 12122560 [PubMed - indexed for MEDLINE]Related articles

34.

Air pollution combustion emissions: characterization of causative agents and mechanisms associated with cancer, reproductive, and cardiovascular effects.

Lewtas J.

Mutat Res. 2007 Nov-Dec;636(1-3):95-133. Epub 2007 Aug 17. Review.PMID: 17951105 [PubMed - indexed for MEDLINE]Related articles

35.

Nanotechnology safety concerns revisited.

Stern ST, McNeil SE.

Toxicol Sci. 2008 Jan;101(1):4-21. Epub 2007 Jun 30. Review.PMID: 17602205 [PubMed - indexed for MEDLINE]Related articlesFree article

36.

[Epidemiologic research on the environment and health: some methodologic aspects]

Hémon D.

Rev Epidemiol Sante Publique. 1995;43(5):395-411. Review. French.PMID: 7501887 [PubMed - indexed for MEDLINE]Related articles

37.

Environmental and occupational causes of cancer: new evidence 2005-2007.

Clapp RW, Jacobs MM, Loechler EL.

Rev Environ Health. 2008 Jan-Mar;23(1):1-37. Review.PMID: 18557596 [PubMed - indexed for MEDLINE]Related articles

38.

Overview of inhalation exposure techniques: strengths and weaknesses.

Pauluhn J.

Exp Toxicol Pathol. 2005 Jul;57 Suppl 1:111-28. Review.PMID: 16092719 [PubMed - indexed for MEDLINE]Related articles

39.

Occupational risk management of engineered nanoparticles.

Schulte P, Geraci C, Zumwalde R, Hoover M, Kuempel E.

J Occup Environ Hyg. 2008 Apr;5(4):239-49. Review.PMID: 18260001 [PubMed - indexed for MEDLINE]Related articles

40.

Health effects of organic aerosols.

Mauderly JL, Chow JC.

Inhal Toxicol. 2008 Feb;20(3):257-88. Review.PMID: 18300047 [PubMed - indexed for MEDLINE]Related articles

Results: 41 to 56 of 56

41.

Health-related aerosol measurement: a review of existing sampling criteria and proposals for new ones.

Vincent JH.

J Environ Monit. 2005 Nov;7(11):1037-53. Epub 2005 Sep 29. Review.PMID: 16252051 [PubMed - indexed for MEDLINE]Related articlesFree article

42.

Carbon nanotubes: a review of their properties in relation to pulmonary toxicology and workplace safety.

Donaldson K, Aitken R, Tran L, Stone V, Duffin R, Forrest G, Alexander A.

Toxicol Sci. 2006 Jul;92(1):5-22. Epub 2006 Feb 16. Review.PMID: 16484287 [PubMed - indexed for MEDLINE]Related articlesFree article

44.

Epidemiologic evidence of relationships between reproductive and child health outcomes and environmental chemical contaminants.

Wigle DT, Arbuckle TE, Turner MC, Bérubé A, Yang Q, Liu S, Krewski D.

J Toxicol Environ Health B Crit Rev. 2008 May;11(5-6):373-517. Review.PMID: 18470797 [PubMed - indexed for MEDLINE]Related articles

45.

[Alpha-interferon and mental disorders]

Debien C, De Chouly De Lenclave MB, Foutrein P, Bailly D.

Encephale. 2001 Jul-Aug;27(4):308-17. Review. French.PMID: 11686052 [PubMed - indexed for MEDLINE]Related articles

46.

Manufactured nanoparticles: an overview of their chemistry, interactions and potential environmental implications.

Ju-Nam Y, Lead JR.

Sci Total Environ. 2008 Aug 1;400(1-3):396-414. Epub 2008 Aug 19. Review.PMID: 18715626 [PubMed - indexed for MEDLINE]Related articles

47.

Assessing workplace chemical exposures: the role of exposure monitoring.

Harper M.

J Environ Monit. 2004 May;6(5):404-12. Epub 2004 Mar 11. Review.PMID: 15152307 [PubMed - indexed for MEDLINE]Related articlesFree article

48.

Potential pulmonary effects of man-made organic fiber (MMOF) dusts.

Warheit DB, Hart GA, Hesterberg TW, Collins JJ, Dyer WM, Swaen GM, Castranova V, Soiefer AI, Kennedy GL Jr.

Crit Rev Toxicol. 2001 Nov;31(6):697-736. Review.PMID: 11763480 [PubMed - indexed for MEDLINE]Related articles

49.

Occupational exposures and reproductive health: 2003 Teratology Society Meeting Symposium summary.

Grajewski B, Coble JB, Frazier LM, McDiarmid MA.

Birth Defects Res B Dev Reprod Toxicol. 2005 Apr;74(2):157-63. Review.PMID: 15834899 [PubMed - indexed for MEDLINE]Related articles

50.

Nanoparticles: health effects--pros and cons.

Gwinn MR, Vallyathan V.

Environ Health Perspect. 2006 Dec;114(12):1818-25. Review.PMID: 17185269 [PubMed - indexed for MEDLINE]Related articlesFree article

51.

Evaluating the health risk from secondary sulfates in eastern North American regional ambient air particulate matter.

Grahame T, Schlesinger R.

Inhal Toxicol. 2005 Jan;17(1):15-27. Review.PMID: 15764480 [PubMed - indexed for MEDLINE]Related articles

52.

Health effects of outdoor air pollution. Committee of the Environmental and Occupational Health Assembly of the American Thoracic Society.

[No authors listed]

Am J Respir Crit Care Med. 1996 Jan;153(1):3-50. Review.PMID: 8542133 [PubMed - indexed for MEDLINE]Related articles

53.

Radiation in the workplace-a review of studies of the risks of occupational exposure to ionising radiation.

Wakeford R.

J Radiol Prot. 2009 Jun;29(2A):A61-79. Epub 2009 May 19. Review.PMID: 19454806 [PubMed - indexed for MEDLINE]Related articles

54.

Quantifying health effects from the combined action of low-level radiation and other environmental agents: can new approaches solve the enigma?

Burkart W, Finch GL, Jung T.

Sci Total Environ. 1997 Oct 7;205(1):51-70. Review.PMID: 9352670 [PubMed - indexed for MEDLINE]Related articles

55.

Airborne particulate matter and human health: toxicological assessment and importance of size and composition of particles for oxidative damage and carcinogenic mechanisms.

Valavanidis A, Fiotakis K, Vlachogianni T.

J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2008 Oct-Dec;26(4):339-62. Review.PMID: 19034792 [PubMed - indexed for MEDLINE]Related articles

56.

Cigarettes with defective filters marketed for 40 years: what Philip Morris never told smokers.

Pauly JL, Mepani AB, Lesses JD, Cummings KM, Streck RJ.

Tob Control. 2002 Mar;11 Suppl 1:I51-61. Review.PMID: 11893815 [PubMed - indexed for MEDLINE]Related articlesFree article



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